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1 An intralesional injection is the direct injection of a therapeutic substance into a lesion or into the skin. Patients underwent a total of 6 i…. A pilot study [37] showed promising results with an intralesional how to get actos in the us injection of verapamil into plaques caused by Peyronie’s disease. Publication types Review MeSH terms. Multiple treatment options have been used for Peyronie's disease (PD) including intralesional injection of the calcium antagonist verapamil. The aim of this studyis to determine the efficacy of intralesional injection ofverapamil over normal saline. Methods: this was a randomized parallel group studyconducted between march 2013 and. The purpose of the present study was to test the effect of intralesional verapamil in a single-blind, placebo-based study. This randomized clinical trial was carried out between March 2005 and March 2006. 17, 18 According to the recommendations of the International Scar Management Advisory Group, the sequential treatment of HSs should be combined with silicone gel sheets, intralesional injection of drugs, laser treatment, surgical excision, and other therapies. The effectiveness and safety of intralesional injection of different drugs to treat HSs and keloids have been controversial for years. Intralesional verapamil injection significantly improved sexual function (p . At present, verapamil is the only calcium channel blocker available in injectable form. Patients were randomly allocated using random numbers (Ralloc Soft Ware) to receive intralesional injection of 1ml of either verapamil (2. Clinical assessment of the scars was performed at the beginning of the study and at 3 week intervals after starting treatment.. Intralesional verapamil injection for Peyronie's disease could reduce pain, decrease penile curvature, and improve sexual function. 5 mg) or triamcinolone (40mg) every 3 weeks. Injection of verapamil is clinically safe for patients with Peyronie's disease, and it appears to induce a rapid, beneficial effect in patients for the reduction of plaque size. The use of verapamil is based on its capacity to alter fibroblast function at several levels, including cell proliferation, extracellular matrix protein synthe …. Intralesional Verapamil Injection for the Treatment of Peyronie's Disease - PubMed Peyronie's disease remains a therapeutic dilemma for the practicing urologist.