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Xyzal contains levocetirizine, an antihistamine previously only available by prescription. Histamine can produce symptoms such as a runny nose or hives. Xyzal Allergy 24HR, from Sanofi, contains levocetirizine, an antihistamine previously only available with a prescription Yes, Xyzal Allergy 24HR is available without a prescription as an over-the-counter (OTC) product for the treatment of seasonal and year-round allergy symptoms. I am going to go off them soon Yes, Xyzal Allergy 24HR (oral tablets) and Children's Xyzal Allergy 24HR (liquid) are available over-the-counter (OTC) for treatment of symptoms due to seasonal and year-round allergies. Xyzal (Levocetirizine) and Claritin (Loratadine) are antihistamines available over the counter in the United States. Xyzal is an antihistamine that reduces the effects of natural chemical histamine in the body. Xyzal is produced by Sanofi, and Zyrtec is produced by a division of Johnson & Johnson. 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